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KMID : 1134820140430040491
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Journal of the Korean Society of Food Science and Nutrition
2014 Volume.43 No. 4 p.491 ~ p.497
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Effects of Alginate Oligosaccharide on Lipid Metabolism in Mice Fed a High Cholesterol Diet
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Back Su-Yeon
Kim Hyun-Ku
Jeong Seung-Ki
DO Jung-Ryong
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Abstract
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This study investigated the effects of alginate oligosaccharide on lipid metabolism in mice fed a high-cholesterol diet for 6 weeks. Male apoE mice were assigned to four groups: normal diet group (N), high-cholesterol diet group (HC), HC with 5% alginate oligosaccharide group (HC-AOL), and 10% alginate oligosaccharide group (HC-AOH). Epididymal adipose tissue and kidney adipose tissue weights were significantly reduced in the HC-AOH group by 131.4% and 148.4%, respectively, as compared to the HC group. Serum total cholesterol (TC), triglyceride (TG), and LDL-cholesterol levels were also significantly reduced in the HC-AOH group by 57.5%, 51.4%, and 82.9%, respectively, as compared to the HC group. Hepatic TC and TG levels in the HC-AOH group were significantly reduced by 72.3% and 33.5%, respectively, as compared to the HC group. These results indicate that alginate oligosaccharide might improve lipid metabolism and reduce fat accumulation.
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KEYWORD
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alginate oligosaccharide, body fat, serum lipid, hepatic lipid
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